School of Pharmacy, Fudan University Publications
Ten studies from the lab’s principal research areas. Each entry identifies the study scope and links to the original DOI.
Journal of Controlled Release · 388 · 114263
Dissolving microneedles preserved SARS-CoV-2 mRNA lipid nanoparticles for at least 30 days at room temperature under study conditions. The team also measured immune responses in mice after skin delivery.
Formulation & mouse immunogenicity
Drug Delivery and Translational Research · 14(11) · 3112–3127
Freeze-drying produced porous needles, followed by coating and insertion testing. With insulin as a model payload, the freeze-dried patch retained more insulin during accelerated storage.
Fabrication & stability
International Journal of Pharmaceutics · 627 · 122207
Sodium hyaluronate microneedles carried tacrolimus nanocrystals for local delivery. The formulation was evaluated in a mouse model of psoriasis-like skin inflammation.
Formulation & mouse model
International Journal of Pharmaceutics · 612 · 121332
A recombinant hirudin patch was assessed for dissolution in skin, permeation, and rat pharmacokinetics, with systemic exposure compared against subcutaneous injection.
Formulation & animal pharmacokinetics
Drug Delivery · 23(1) · 147–153
A lymph duct-cannulated rat model was used to examine how a lipid vehicle and P-glycoprotein inhibition influenced paclitaxel transport into lymph.
Animal absorption study
AAPS PharmSciTech · 15(5) · 1149–1154
The study used rheology to compare the viscoelastic behavior of cross-linked, partially neutralized polyacrylate hydrogel bases.
Matrix characterization
Biological and Pharmaceutical Bulletin · 36(6) · 931–937
In a crossover study in healthy volunteers, the tested tetramethylpyrazine patch and oral tetramethylpyrazine phosphate regimens produced similar steady-state exposure. The study also evaluated in vitro–in vivo correlation.
Healthy-volunteer pharmacokinetics
Drug Delivery · 20(1) · 19–24
Eucalyptus oil was assessed as a permeation enhancer in a reservoir patch, with formulation performance investigated through ex vivo skin permeation and rabbit pharmacokinetics.
Skin permeation & animal pharmacokinetics
Pharmazie · 68(3) · 170–172
Rat pharmacokinetics were compared across oral doses and an intravenous reference. Oral exposure increased less than proportionally with dose.
Animal pharmacokinetics
Journal of Pharmaceutical and Biomedical Analysis · 71 · 202–206
The study developed and validated an LC–MS/MS assay for bulleyaconitine A in rat plasma and applied it to an oral pharmacokinetics study.
Bioanalysis & animal pharmacokinetics
